OSAKA, Japan and MONTREAL , Dec. 5, 2024 /PRNewswire/ -- Ono Pharmaceutical Co., Ltd. (Headquarters: Osaka, Japan ; President: Toichi Takino; "Ono") announced that it has entered into a drug discovery collaboration agreement with Congruence Therapeutics (Headquarters: Montreal, Quebec, Canada ; CEO: Clarissa Desjardins; "Congruence") to generate novel small molecule correctors against multiple protein targets in the oncology area by leveraging Congruence's proprietary drug discovery platform, RevenirTM. Under the terms of the agreement, Congruence will generate small molecule correctors by leveraging Congruence's proprietary drug discovery engine called, RevenirTM. Ono will obtain an exclusive option right to develop, manufacture and commercialize the identified small molecule correctors worldwide. Congruence will be eligible to receive an upfront payment, research expenses, milestone payments based on research and development progress and sales, as well as tiered royalties based on net sales. "We believe that this collaboration with Congruence may help generating novel small molecule correctors for validated targets in the oncology area by leveraging their own technologies in protein dynamics and computational biology, leading to our development pipeline," said Seishi Katsumata , Corporate Officer / Executive Director, Discovery & Research of Ono. "We will be committed to delivering innovative new drugs to cancer patients as soon as possible." "Congruence is thrilled to partner with Ono, which has established itself as a global leader in drug development, particularly in the oncology space. We believe that our RevenirTM platform and capabilities in protein dynamics will accelerate the discovery of novel therapies for compelling targets of interest to both companies," said Sharath Hegde PhD, Chief Scientific Officer of Congruence. About RevenirTM Drug Discovery Platform RevenirTM, Congruence's proprietary computational drug discovery platform, captures the dynamic biophysical changes caused by mutations in proteins, offering unique insights into protein defects and their correction. By examining surface features and a spectrum of biophysical descriptors across an ensemble of protein conformers, RevenirTM predicts small molecule induced correction of the underlying defect. About Congruence Therapeutics Congruence is a computationally-driven biotechnology company building a unique pipeline of transformative small molecule correctors rationally designed to rescue aberrant protein function. Congruence's proprietary scalable platform, RevenirTM, captures the biophysical features of proteins across their conformational ensembles, in order to identify novel allosteric and cryptic pockets which are virtually screened to generate novel chemical matter. For more information, please visit www.congruencetx.com . View original content to download multimedia: https://www.prnewswire.com/news-releases/ono-enters-into-drug-discovery-collaboration-agreement-with-congruence-therapeutics-to-generate-novel-small-molecule-correctors-in-the-oncology-area-302324452.html SOURCE Ono Pharmaceutical co., ltd.best bookmaker offers 。

Flag football uses talent camps to uncover new starsNEW YORK , Dec. 5, 2024 /PRNewswire/ -- The Board of Directors of Omnicom (NYSE: OMC) declared a quarterly dividend of 70 cents per outstanding share of the corporation's common stock. The dividend is payable on January 10, 2025 to Omnicom common shareholders of record at the close of business on December 20, 2024. About Omnicom Omnicom (NYSE: OMC) is a leading provider of data-inspired, creative marketing and sales solutions. Omnicom's iconic agency brands are home to the industry's most innovative communications specialists who are focused on driving intelligent business outcomes for their clients. The company offers a wide range of services in advertising, strategic media planning and buying, precision marketing, retail and digital commerce, branding, experiential, public relations, healthcare marketing and other specialty marketing services to over 5,000 clients in more than 70 countries. For more information, visit www.omnicomgroup.com . View original content to download multimedia: https://www.prnewswire.com/news-releases/omnicom-declares-dividend-302324450.html SOURCE Omnicom Group Inc.

Timeline: Jimmy Carter, 1924-2024None

None

How co-writing a book threatened the Carters’ marriage

British Columbia Premier David Eby says Canada’s premiers and the federal government have hatched a game plan over possible U.S. tariffs, where Conservative premiers lobby their Republican counterparts and left-leaning leaders court the Democrats, while the federal government focuses on president-elect Donald Trump. Eby says the premiers and Prime Minister Justin Trudeau talked about using their political diversity and connections to approach politicians and business leaders in the United States, as talks over Trump’s proposed 25 per cent tariff on imports from Canada and Mexico ramp up. He says it has been discussed that Conservative premiers Danielle Smith in Alberta, Doug Ford in Ontario and Nova Scotia’s Tim Houston are well-placed to lobby their contacts with Republican governors and business leaders. In a year-end interview, Eby says as a New Democrat leader he will likely have more in common speaking with Democrat governors and business leaders from the West Coast states. He says Canada’s diversity of representation, ranging from the right and left sides of the political spectrum, can bring leverage and advantages in tariff talks. Eby also says — if it is deemed helpful — he is prepared to appear on American’s right-leaning Fox News TV network as did premiers Ford and Smith.

Former President Jimmy Carter has died at the age of 100. The 39th president of the United States was a Georgia peanut farmer who sought to restore trust in government when he assumed the presidency in 1977 and then built a reputation for tireless work as a humanitarian. He earned a Nobel Peace Prize in 2002. He died Sunday, more than a year after entering hospice care, at his home in Plains, Georgia. At age 52, Carter was sworn in as president on Jan. 20, 1977, after defeating President Gerald R. Ford in the 1976 general election. Carter left office on Jan. 20, 1981, following his 1980 general election loss to Ronald Reagan. Here's the latest: The longest-lived American president died Sunday, more than a year after entering hospice care , at his home in the small town of Plains, Georgia, where he and his wife, Rosalynn, who died at 96 in November 2023 , spent most of their lives. “Our founder, former U.S. President Jimmy Carter, passed away this afternoon in Plains, Georgia,” The Carter Center said in posting about his death on the social media platform X. It added in a statement that he died peacefully, surrounded by his family. In his 1975 book “Why Not The Best,” Carter said of himself: “I am a Southerner and an American, I am a farmer, an engineer, a father and husband, a Christian, a politician and former governor, a planner, a businessman, a nuclear physicist, a naval officer, a canoeist, and among other things a lover of Bob Dylan’s songs and Dylan Thomas’s poetry.” A moderate Democrat, Carter entered the 1976 presidential race as a little-known Georgia governor with a broad smile, outspoken Baptist mores and technocratic plans reflecting his education as an engineer. After he left office and returned home to his tiny hometown of Plains in southwest Georgia, Carter regularly taught Sunday School lessons at Maranatha Baptist Church until his mobility declined. Those sessions drew visitors from around the world. Former Vice President Al Gore praised Jimmy Carter for living “a life full of purpose, commitment and kindness” and for being a “lifelong role model for the entire environmental movement.” Carter, who left the White House in 1981 after a landslide defeat to Ronald Reagan. concentrated on conflict resolution, defending democracy and fighting disease in the developing world. Gore, who lost the 2000 presidential election to George W. Bush, remains a leading advocate for action to fight climate change. Both won Nobel Peace Prizes. Gore said that “it is a testament to his unyielding determination to help build a more just and peaceful world” that Carter is often “remembered equally for the work he did as President as he is for his leadership over the 42 years after he left office.” During Gore’s time in the White House, President Bill Clinton had an uneasy relationship with Carter. But Gore said he is “grateful” for “many years of friendship and collaboration” with Carter. Former President Bill Clinton and his wife, former Secretary of State Hillary Clinton, remember Carter as a man who lived to serve others. “Hillary and I mourn the passing of President Jimmy Carter and give thanks for his long, good life. Guided by his faith, President Carter lived to serve others — until the very end." The statement recalled Carter's many achievements and priorities, including efforts “to protect our natural resources in the Arctic National Wildlife Refuge, make energy conservation a national priority, return the Panama Canal to Panama, and secure peace between Egypt and Israel at Camp David." After he left office, the Clinton statement said, Carter continued efforts in "supporting honest elections, advancing peace, combating disease, and promoting democracy; to his and Rosalynn’s devotion and hard work at Habitat for Humanity — he worked tirelessly for a better, fairer world,” the statement said.Timeline: Jimmy Carter, 1924-2024

In attack, Manchester City boasts a formidable strike force led by the likes of Raheem Sterling, Riyad Mahrez, and Gabriel Jesus. The team's forward line is known for its pace, movement, and clinical finishing, posing a constant threat to opposition defenses. With players who can create chances out of nothing and convert them with ease, Manchester City has been able to outscore their opponents consistently.

Mayor Eric Adams said Tuesday that he is ready to sit down with Republican President-elect Donald Trump and his rapidly developing cabinet while reiterating that he wants to work rather than war with the incoming administration. During his weekly press conference, Hizzoner said he has communicated to the burgeoning Trump administration that City Hall would like to engage with them on several of the city’s most pressing issues. “We communicated that once things are in order we would like to sit down and share some of our ideas and visions around the border, around affordability, around New York City needs,” Adams said. “He was receptive to that. Our goal is not to be warring, but working, with the new president for New York City. Not four years of fighting, but four years of working.” During the briefing, the mayor also took issue with those criticizing Trump’s highly controversial cabinet appointments — including anti-vaccine advocate Robert F. Kennedy Jr. for Secretary of Health and former Fox News personality Pete Hegseth for Secretary of Defense. He suggested those who do not like Trump’s picks should run for office themselves instead of criticizing him. “He ran, he went across the country, he went to rallies,” Adams said. “The person who did the sweat, blood and tears, now he has to pick his team. Those who say ‘I don’t like who you picked,’ then run. No one stops anyone from running and being the president.” The Democratic mayor’s lastest comments fit into his noticeably soft rhetoric around Trump over the past few months—compared with most other leaders in his party . His efforts to seemingly tiptoe around criticizing Trump have come under fire, as some critics speculate the mayor might be angling for the incoming president to help with his legal troubles. Mayor Adams bristled last week at the notion that he is trying to curry favor with Trump to help his legal case, noting that after he reached out to the president-elect, so did Gov. Kathy Hochul, US Sen. Kirsten Gillibrand and MSNBC host Joe Scarborough. “None of them, not the governor, not the senator, not Morning Joe, did you say, ‘are you doing it because you want something?'” Adams said last week. “How about we’re doing it because we love New York? This is the president. And it’s time for us to stop yelling at each other and working with each other.” Adams pleaded not guilty to a five-count federal indictment in late September and will go on trial for the charges on April 21 of next year. Prosecutors allege that he sought and accepted luxury travel perks and illegal foreign campaign contributions in exchange for political favors on behalf of the Turkish government. Trump has publicly belittled the charges against Adams and cast him, without evidence, as the target of political persecution from President Biden’s Justice Department. The president-elect pardoned many of his political allies during his first term in office, and Adams’ legal team reportedly believed he could do the same for the embattled mayor. Trump is set to nominate Jay Clayton — his former Securities and Exchange Commission head — to take over as the US Attorney for the Southern District of New York, the office that indicted Adams. Damian Williams, the current US Attorney for SDNY, announced Monday that he would resign next month .Victoria's Capital City Comic Con announces it won't return

The competition will be spread across four main zones, each offering its own unique atmosphere and challenges. The Alpine Zone will showcase the heart-pounding action of alpine skiing, snowboarding, and freestyle skiing events. Athletes will navigate steep slopes, sharp turns, and challenging obstacles as they battle for Olympic glory in disciplines like downhill, slalom, and snowboard cross. Spectators can expect edge-of-the-seat excitement and breathtaking displays of skill and courage in this zone.To their surprise, the oversized suitcases belonging to Mr. X and Ms. Y were found to be overflowing with an extravagant assortment of luxury items, ranging from designer clothing and accessories to high-end electronics and rare collectibles. The sheer volume and opulence of the items raised eyebrows among the officials, who promptly seized the goods for further investigation.