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- 2025-01-11 Author: Hua Erjun Source: http://admin.turflak.no/cpresources/twentytwentyfive/
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LANDOVER, Md. (AP) — The ball bounced through KaVonte Turpin's legs and stopped at the 1-yard line. He picked it up, made a spin move and was off to the races. Read this article for free: Already have an account? To continue reading, please subscribe: * LANDOVER, Md. (AP) — The ball bounced through KaVonte Turpin's legs and stopped at the 1-yard line. He picked it up, made a spin move and was off to the races. Read unlimited articles for free today: Already have an account? LANDOVER, Md. (AP) — The ball bounced through KaVonte Turpin’s legs and stopped at the 1-yard line. He picked it up, made a spin move and was off to the races. Turpin’s 99-yard kickoff return touchdown was the highlight of the Dallas Cowboys’ 34-26 win at Washington on Sunday that ended their losing streak at five. That came with just under three minutes left, and then Juanyeh Thomas returned an onside kick for a TD to provide a little happiness in the middle of a lost season. “Feels good to win,” coach Mike McCarthy said. “It’s been a minute.” Chauncey Golston ripping the ball out of Brian Robinson Jr.’s hands for what counted as an interception of Commanders rookie quarterback Jayden Daniels and Donovan Wilson forcing a fumble of John Bates earlier in the game helped put the Cowboys in position to make it a game, as did the play of Cooper Rush. Turpin’s monster return after initially muffing the retrieval had everyone buzzing. “He did that for timing,” McCarthy said. “That was part of the plan. He’s a special young man. Obviously a huge play for us.” Commanders safety Jeremy Reaves, the All-Pro special teams selection two seasons ago, was the first one down the field and blamed himself for not tackling Turpin when he had the chance. “I’ve made that play 100 times,” Reaves said. “I didn’t make it today, and it cost us the game.” Turpin’s spin move will likely be replayed over and over — and not stopped by many. Receiver CeeDee Lamb called it “his escape move” because Turpin has been showing it off in practice. “I know I can just get them going one way and then spin back the other way,” Turpin said. “That’s just one of my moves when I’m in trouble and I’ve got nowhere to go: something nobody ever seen before.” In a wacky finish that McCarthy likened to a game of Yahtzee, Thomas’ return was almost as unexpected. It came with 14 seconds left after Washington kicker Austin Seibert missed the extra point following Daniels’ 86-yard touchdown pass to Terry McLaurin to leave Dallas up 27-26. Winnipeg Jets Game Days On Winnipeg Jets game days, hockey writers Mike McIntyre and Ken Wiebe send news, notes and quotes from the morning skate, as well as injury updates and lineup decisions. Arrives a few hours prior to puck drop. “I kind of waited a second and I was like: ‘Should I try? Should I try?’” Thomas said. “I said, ‘I think I’m gonna score the ball,’ so just ran and I scored.” The Cowboys’ playoff odds are still incredibly long at 4-7, but with the New York Giants coming to town next for the traditional Thanksgiving Day game at Dallas, players are willing to dream after winning for the first time since Oct. 6. “Lot of games left,” said Rush, who threw two TD passes. “Pretty insane. ... I think both sides of the ball and special teams picked each other up all game. I think it was a full team effort. Finally picking each other up like we’re supposed to.” ___ AP NFL: https://apnews.com/hub/nfl Advertisement AdvertisementThe cost of Neom has been estimated to be as high as $1.5 trillion. This year, however, has seen a sharp change in direction in terms of spending for the kingdom. "Saudi Arabia has poured tens of billions into projects that have yet to hint of any financial returns," one financier told CNBC. 24/7 San Diego news stream: Watch NBC 7 free wherever you are In Saudi Arabia's northwestern desert, a sprawling construction site replete with cranes and pile drivers sits encircled by a recently-built road. A pair of tracks cuts through the site like deep gashes through the sand, comprising the spine of what planners say will be a high-speed rail system. The skeletal infrastructure forms the foundations of The Line, a multi-billion dollar high-tech city that its architects say will eventually house 9 million people between two 106-mile long glass skyscrapers more than 1,600 feet high. The project, whose estimated cost is in the hundreds of billions, is just one of the hyper-futuristic venues planned in Neom, the brainchild of Saudi Crown Prince Mohammed bin Salman and a region that the kingdom hopes will bring millions of new residents to Saudi Arabia and revolutionize living and technology in the country. It's a core pillar of Vision 2030, which aims to diversify the Saudi economy away from oil revenues and create new jobs and industries for its burgeoning young population. The cost of Neom has been estimated to be as high as $1.5 trillion . In the years since it was announced, Saudi Arabia's Public Investment Fund, the mammoth sovereign wealth fund now overseeing $925 billion in assets, has poured billions into overseas investments, with ever-increasing waves of foreign investors flying to the kingdom to raise cash. This year, however, has seen a sharp change in direction in terms of spending, with a stated emphasis on keeping investments at home along with reports of cutting costs on megaprojects like those in Neom. The changes come as the Saudi deficit grows and the outlook for oil demand, along with global oil prices, sees sustained lows. That begs the question: does Saudi Arabia have enough money to meet its lofty goals? Or will it have to be more flexible to make its spending trajectory sustainable? Money Report European stocks set to start the week higher as global markets rally China's central bank keeps medium-term loan rate unchanged amid yuan weakness One Gulf-based financier with years of experience in the kingdom told CNBC: "The PIF's pivot towards domestic investments, widely acknowledged but now officially admitted, suggests that there is still a lot of spending needed. Saudi Arabia has poured tens of billions into projects that have yet to hint of any financial returns." The financier spoke anonymously as they were not authorized to speak to the press. Andrew Leber, a researcher at Tulane University who focuses on the political economy of the Middle East, believes that the current pace of spending won't last. "The number of 'we pay up front and hope for economic returns later' giga projects that are currently underway is not sustainable," Leber said. "With that being said," he added, "the Saudi monarchy has shown itself to be somewhat flexible whenever economic realities assert themselves. I do think that eventually, a number of projects will be quietly shelved in order to bring its fiscal outlays back into greater sustainability." Saudi Arabia in October cut its growth forecasts and raised its budget deficit estimates for the fiscal years 2024 to 2026 as it expects a period of higher spending and lower projected oil revenues. Real gross domestic product is now expected to grow 0.8% this year, a dramatic drop from a previous estimate of 4.4%, according to the ministry of finance. The kingdom's economy also swung dramatically from a budget surplus of $27.68 billion in 2022 to a deficit of $21.6 billion in 2023 as it ramped up public spending and decreased oil production due to its OPEC+ supply cut agreement. Its government forecasts a deficit of $21.1 billion for 2024, projecting revenue at $312.5 billion and expenditures at $333.5 billion. Saudi authorities expect that the budget will remain in deficit for the next several years as it pursues its Vision 2030 plans, but they add that they are fully prepared for this. "Our non-oil revenues have grown significantly, now it covers about 37% of expenditure. That's a significant diversification, and that gives you a lot of comfort that you can maneuver and be stable despite the fluctuation in oil price," Saudi Finance Minister Mohammed Al-Jadaan told CNBC in October. "Our aim is to make sure that our plans are stable and predictable." "We are not going to blink, we have significant fiscal resource under our disposal, and we are very disciplined in our fiscal position," the minister said. Saudi Arabia has an A/A-1 credit rating with a positive outlook from S&P Global Ratings and an A+ rating with a stable outlook from Fitch. That combined with high foreign currency reserves — $456.97 billion as of September, a 4% percent increase year-on-year, according to the country's central bank — puts the kingdom in a comfortable place to manage a deficit, economists told CNBC. Riyadh is successfully issuing bonds, tapping debt markets for more than $35 billion so far this year. The kingdom has also rolled out a series of reforms to boost and de-risk foreign investment and diversify revenue streams, which S&P Global said in September "will continue to improve Saudi Arabia's economic resilience and wealth." When asked if the kingdom's spending trajectory is sustainable, Al-Jadaan replied: "Absolutely, yes," adding that the government recently published its numbers for the next three years and that "we think it is very sustainable." Still, many analysts outside the kingdom, as well as individuals working within the kingdom and on NEOM projects, are skeptical of the megaprojects' feasibility. Reports that some projects have been dramatically cut down — in the case of the Line, its size target slashed from 106 miles to 1.5 miles and population target down from 1.5 million by 2030 to less than 300,000 — attest to that concern on a higher level. Neom executives acknowledge that the current phase of work on The Line is for a building length of 1.5 miles — which would still make it the longest building in the world. However, the eventual goal of 106 miles has not changed, they say, stressing that cities are not built overnight and that construction is continuing apace. For Tarik Solomon, chairman emeritus at the American Chamber of Commerce in Saudi Arabia, "it's promising to see transparency and some project cutbacks." "The Kingdom's rising external borrowing reflects challenges with Vision 2030 feasibility," he told CNBC. "Though debt remains manageable at 26.5% of GDP, continued small pressures add up, underscoring the need for fiscal discipline and achievable goals." Solomon pointed to the desire of many Saudi residents for improvements to the infrastructure they use in their daily lives — like Riyadh's public transport, network connectivity, schools, and health care. "The road to resilience for Saudi Arabia isn't in figuring out ski slopes in the desert but in building with innovation, complexity, and the courage to pursue what's truly impactful," he said. Also on CNBC Donald Trump chooses hedge fund executive Scott Bessent for Treasury secretary Trump might name Kevin Warsh as Treasury chief then Fed chair later, report says Trump and Fed Chair Powell could be set on a collision course over interest rates
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New gene drive reverses insecticide resistance in pests... then disappears November 22, 2024 University of California - San Diego Geneticists have developed a gene drive-based solution to the widespread problem of insecticide resistance. In an effort to protect valuable crops, the researchers created an 'e-Drive' that reverses insecticide resistance and then disappears from the insect population. Facebook Twitter Pinterest LinkedIN Email Insecticides have been used for centuries to counteract widespread pest damage to valuable food crops. Eventually, over time, beetles, moths, flies and other insects develop genetic mutations that render the insecticide chemicals ineffective. Escalating resistance by these mutants forces farmers and vector control specialists to ramp up use of poisonous compounds at increasing frequencies and concentrations, posing risks to human health and damage to the environment since most insecticides kill both ecologically important insects as well as pests. To help counter these problems, researchers recently developed powerful technologies that genetically remove insecticide-resistant variant genes and replace them with genes that are susceptible to pesticides. These gene-drive technologies, based on CRISPR gene editing, have the potential to protect valuable crops and vastly reduce the amount of chemical pesticides required to eliminate pests. Still, gene-drive systems have come under scrutiny with concerns that once they are released into a population they could continuously spread unchecked. University of California San Diego geneticists have now developed a solution to this concern. Publishing in the journal Nature Communications , School of Biological Sciences Postdoctoral Scholar Ankush Auradkar and Professor Ethan Bier led the creation of a new genetic system that converts insecticide-resistant forms of mutated insect genes back to their natural, native form. The novel system is designed to spread the original "wild type" version of the gene using the biased inheritance of specific genetic variants known as alleles and then disappear, leaving only a population of insects with the corrected version of the gene. "We have developed an efficient biological approach to reverse insecticide resistance without creating any other perturbation to the environment," said Bier, a professor in the Department of Cell and Developmental Biology, of the self-eliminating allelic drive, or "e-Drive." "The e-Drive is programmed to act transiently and then disappear from the population." As described in the paper, the researchers created a novel genetic "cassette," a small group of DNA elements, and inserted it inside fruit flies as a proof-of-concept technology that could be applied to other insects. They developed the e-Drive to target a gene known as the voltage gated sodium ion channe l, or vgsc , which is required for proper nervous system functioning. The e-Drive cassette is designed to spread through CRISPR gene editing and features a guide RNA that binds to a Cas9 DNA protein and makes a cut at the targeted vgsc insecticide resistant gene site. The gene is then switched out for a native copy of the gene that is susceptible to insecticides. Per the study, when insects carrying the cassette are introduced into a target population, they mate randomly and transmit the e-Drive cassette to their offspring. To maintain control of the e-Drive's spread, the researchers imposed a fitness check on those carrying the cassette, either through limited viability or fertility. The cassette was inserted on the X-chromosome and reduced the mating success of males, resulting in reduced offspring. The frequency of the cassette in the population eventually declines through each generation until it fully vanishes from the population. In laboratory experiments all of the offspring were converted to native genes in eight-to-10 generations, which took about six months in flies. "Because insects carrying the gene cassette are penalized with a severe fitness cost, the element is rapidly eliminated from the population, lasting only as long as it takes to convert 100 percent of the insecticide-resistant forms of the target gene back to wild-type," said Auradkar. The researchers note that the self-eliminating nature of the e-Drive means it can be introduced and re-introduced as needed, and as different types of pesticides are used. The researchers are now developing a similar e-Drive system in mosquitoes to help prevent the spread of malaria. In addition to Auradkar and Bier, the coauthors of the Nature Communications paper included their close collaborators Rodrigo Corder of the Institute of Biomedical Science, University of SãoPaulo; and John Marshall of the Innovative Genomics Institute, who performed sophisticated mathematical modeling that revealed important hidden features of the e-Drive system, including its ability to efficiently cull a class of individuals in which the drive process did not occur. Story Source: Materials provided by University of California - San Diego . Original written by Mario Aguilera. Note: Content may be edited for style and length. Journal Reference : Cite This Page :Zymeworks Inc. ( NYSE:ZYME – Get Free Report ) Director Ecor1 Capital, Llc bought 11,958 shares of the firm’s stock in a transaction that occurred on Tuesday, December 24th. The shares were acquired at an average price of $14.12 per share, with a total value of $168,846.96. Following the purchase, the director now owns 14,704,239 shares in the company, valued at $207,623,854.68. This trade represents a 0.08 % increase in their ownership of the stock. The acquisition was disclosed in a filing with the Securities & Exchange Commission, which is available at this hyperlink . Ecor1 Capital, Llc also recently made the following trade(s): Zymeworks Price Performance NYSE:ZYME opened at $14.50 on Friday. The business’s 50-day simple moving average is $14.25 and its 200-day simple moving average is $12.00. Zymeworks Inc. has a fifty-two week low of $7.97 and a fifty-two week high of $17.70. The stock has a market capitalization of $998.73 million, a PE ratio of -9.67 and a beta of 1.12. Wall Street Analysts Forecast Growth ZYME has been the topic of several recent analyst reports. Leerink Partners raised Zymeworks from a “market perform” rating to an “outperform” rating and boosted their target price for the stock from $10.00 to $25.00 in a report on Thursday, November 7th. Leerink Partnrs raised Zymeworks from a “hold” rating to a “strong-buy” rating in a report on Thursday, November 7th. Wells Fargo & Company raised their price objective on shares of Zymeworks from $12.00 to $14.00 and gave the company an “equal weight” rating in a research report on Thursday, December 19th. Stifel Nicolaus upped their price objective on Zymeworks from $21.00 to $28.00 and gave the stock a “buy” rating in a report on Monday, October 28th. Finally, JPMorgan Chase & Co. upgraded shares of Zymeworks from a “neutral” rating to an “overweight” rating and set a $18.00 target price on the stock in a research report on Monday, December 16th. Two equities research analysts have rated the stock with a hold rating, four have given a buy rating and one has given a strong buy rating to the company’s stock. Based on data from MarketBeat.com, the company has a consensus rating of “Moderate Buy” and an average target price of $19.17. View Our Latest Stock Analysis on ZYME Institutional Inflows and Outflows Several institutional investors and hedge funds have recently modified their holdings of the company. Bank of New York Mellon Corp lifted its stake in Zymeworks by 5.0% in the 2nd quarter. Bank of New York Mellon Corp now owns 309,703 shares of the company’s stock valued at $2,636,000 after purchasing an additional 14,825 shares during the last quarter. Principal Financial Group Inc. raised its position in shares of Zymeworks by 18.0% in the second quarter. Principal Financial Group Inc. now owns 30,642 shares of the company’s stock valued at $261,000 after purchasing an additional 4,671 shares during the period. BNP PARIBAS ASSET MANAGEMENT Holding S.A. lifted its stake in shares of Zymeworks by 1.2% during the 2nd quarter. BNP PARIBAS ASSET MANAGEMENT Holding S.A. now owns 1,930,887 shares of the company’s stock worth $16,431,000 after buying an additional 23,173 shares during the last quarter. Rhumbline Advisers boosted its holdings in shares of Zymeworks by 9.0% during the 2nd quarter. Rhumbline Advisers now owns 86,912 shares of the company’s stock worth $740,000 after buying an additional 7,210 shares during the period. Finally, Victory Capital Management Inc. grew its stake in Zymeworks by 23.5% in the 2nd quarter. Victory Capital Management Inc. now owns 58,300 shares of the company’s stock valued at $496,000 after buying an additional 11,100 shares during the last quarter. 92.89% of the stock is owned by institutional investors and hedge funds. Zymeworks Company Profile ( Get Free Report ) Zymeworks Inc, a clinical-stage biopharmaceutical company, discovers, develops, and commercializes biotherapeutics for the treatment of cancer. The company’s lead product candidates include zanidatamab, a human epidermal growth factor receptor 2 (HER2) that is in Phase 1, Phase 2, and Phase 3 clinical trials, including certain ongoing pivotal clinical trials; and zanidatamab zovodotin, a HER2 -targeted antibody-drug conjugate that is in Phase 2 clinical trial for the treatment of advanced or metastatic HER2-expressing tumors. Featured Articles Receive News & Ratings for Zymeworks Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for Zymeworks and related companies with MarketBeat.com's FREE daily email newsletter .Mainpuri, December 7: West Bengal Chief Minister Mamata Banerjee's statement expressing her desire to lead the INDIA bloc has sparked a political debate, drawing numerous reactions. Senior Samajwadi Party leader Ram Gopal Yadav, sharing his views on the matter, said that Congress MP Rahul Gandhi is the not the leader of the INDIA bloc, adding that the grand old party's below-par performance in the Lok Sabha and Assembly elections might have made the Trinamool Congress supremo submit her remarks. "In Himachal Pradesh, where the Congress is in power, they lost all four seats. Similarly, in Karnataka and Telangana, both Congress-ruled states, they lost half of their Lok Sabha seats. Furthermore, Congress failed to win even a single seat in Madhya Pradesh. It suffered major losses in Chhattisgarh. Had Congress performed better in the Lok Sabha elections, Narendra Modi would not have become the Prime Minister today. Government Hiking Tax Rates for Common Man, Giving Concessions to Billionaires, Says Rahul Gandhi. "This is the reason the leadership change is being discussed. However, I choose not to engage in this debate. The INDIA alliance must remain intact, as without this alliance, these tikadami (trickster) individuals cannot be defeated," Yadav told reporters. At a press conference in his hometown of Mainpuri, he said: "Doubts about the results in Maharashtra began to grow when people said that their votes were cast for Congress, but Congress' votes didn't show up. This situation points to irregularities. Even Donald Trump had mentioned that Russia interfered with the US presidential election through technology, so in today's technological world, it’s not a big deal. We use disappearing messages on our phones, which vanish in minutes. Such changes can easily be made using technology." ‘Mock Ballot Paper’ Polls in Solapur: Rahul Gandhi, Sharad Pawar May Visit Maharashtra’s Markadwadi. The Samajwadi Party leader believes that "elections must be contested, whether they are by-polls or general elections. They are ready and will fully exercise their democratic rights". Regarding the Sambhal violence, he said: "The BJP is searching temples across the country. The BJP's intention is to create unrest in the country so that they can stay in power. They don’t care about the country." (The above story first appeared on LatestLY on Dec 07, 2024 10:13 PM IST. For more news and updates on politics, world, sports, entertainment and lifestyle, log on to our website latestly.com ).
NVIDIA Co. (NASDAQ:NVDA) Stock Position Decreased by My Legacy Advisors LLCThe South Carolina women's basketball team has been defeated for the first time since March 31, 2023. The No. 1 Gamecocks fell Sunday in Los Angeles as Lauren Betts posted a double-double effort to lead No. 5 UCLA to a 77-62 triumph. The Gamecocks (5-1) suffered their first defeat after 43 consecutive victories, dating back to the loss to Iowa 77-73 in the NCAA Tournament semifinals. South Carolina defeated Iowa last season for the national championship. Betts finished with 11 points, a game-high 14 rebounds, four assists and four blocks to power the Bruins (5-0) to a historic victory. UCLA also got 15 points from Londynn Jones on 5-of-5 shooting from 3-point range, 13 points from Elina Aarnisalo and 11 each from Kiki Rice and Gabriela Jacquez. It's the first time UCLA has beaten South Carolina since 1981. The Bruins lost twice to the Gamecocks in the 2022-23 season, including in the Sweet 16 of the NCAA Tournament. Te-Hina Paopao had 18 points for South Carolina on 4-of-4 3-point shooting, while Tessa Johnson had 14 points. UCLA won the rebounding battle 41-34, marking the second time this season the Gamecocks have been outrebounded. South Carolina also got outscored in the paint 26-18. It's rare that a Dawn Staley-coached team -- units that typically revolve around dominant centers from A'ja Wilson to Aaliyah Boston to Kamilla Cardoso -- gets beat in the paint and on the glass, but with 6-foot-7 Betts, UCLA had the recipe to outmuscle the Gamecocks in those areas of the game. South Carolina never led after UCLA began the game with an 18-5 run, capped off by back-to-back 3-pointers from Jones. The Gamecocks cut the deficit to nine points in the second quarter, but the Bruins responded with a 17-5 run and entered halftime ahead by 21 points. Aarnisalo scored seven points during that run. From there, the Gamecocks never got within single digits of the lead in the second half. It's the first time in 21 tries that UCLA has beaten an AP-ranked No. 1 team. And it's the first time South Carolina lost a true road game since 2021, a streak of 33 games. The schedule doesn't get any easier for South Carolina. While UCLA faces UT Martin next on Friday, the Gamecocks play No. 8 Iowa State on Thursday. --Field Level Media
ADA, XLM and LNEX See Whale Activity Surge Ahead Of 600% Stellar, Lunex and Cardano Price Predictions
Shares of Cullinan Therapeutics, Inc. ( NASDAQ:CGEM – Get Free Report ) traded down 2.9% on Thursday . The stock traded as low as $11.88 and last traded at $11.92. 28,103 shares changed hands during mid-day trading, a decline of 96% from the average session volume of 640,126 shares. The stock had previously closed at $12.27. Analyst Ratings Changes A number of equities analysts have issued reports on CGEM shares. HC Wainwright reiterated a “buy” rating and issued a $28.00 price objective on shares of Cullinan Therapeutics in a report on Wednesday, October 16th. UBS Group initiated coverage on shares of Cullinan Therapeutics in a research note on Thursday, October 24th. They issued a “buy” rating and a $30.00 price target for the company. Finally, Wedbush reissued an “outperform” rating and set a $36.00 price target on shares of Cullinan Therapeutics in a research report on Wednesday, September 18th. Seven research analysts have rated the stock with a buy rating, According to data from MarketBeat.com, the stock currently has a consensus rating of “Buy” and an average target price of $31.67. Check Out Our Latest Analysis on CGEM Cullinan Therapeutics Stock Performance Cullinan Therapeutics ( NASDAQ:CGEM – Get Free Report ) last released its quarterly earnings data on Thursday, November 7th. The company reported ($0.69) earnings per share for the quarter, beating analysts’ consensus estimates of ($0.78) by $0.09. As a group, sell-side analysts anticipate that Cullinan Therapeutics, Inc. will post -3.12 EPS for the current fiscal year. Insider Activity at Cullinan Therapeutics In other Cullinan Therapeutics news, insider Jennifer Michaelson sold 3,489 shares of the business’s stock in a transaction dated Thursday, December 12th. The stock was sold at an average price of $12.52, for a total value of $43,682.28. Following the completion of the transaction, the insider now owns 104,453 shares of the company’s stock, valued at approximately $1,307,751.56. The trade was a 3.23 % decrease in their position. The sale was disclosed in a filing with the Securities & Exchange Commission, which can be accessed through this hyperlink . Also, CEO Nadim Ahmed sold 8,400 shares of the company’s stock in a transaction dated Tuesday, December 24th. The shares were sold at an average price of $11.87, for a total transaction of $99,708.00. Following the transaction, the chief executive officer now owns 263,150 shares in the company, valued at $3,123,590.50. This represents a 3.09 % decrease in their position. The disclosure for this sale can be found here . In the last three months, insiders have sold 24,582 shares of company stock valued at $322,057. 6.07% of the stock is owned by corporate insiders. Institutional Investors Weigh In On Cullinan Therapeutics A number of large investors have recently added to or reduced their stakes in CGEM. Bank of New York Mellon Corp boosted its stake in shares of Cullinan Therapeutics by 46.4% in the 2nd quarter. Bank of New York Mellon Corp now owns 137,997 shares of the company’s stock worth $2,407,000 after buying an additional 43,757 shares during the last quarter. Zurcher Kantonalbank Zurich Cantonalbank lifted its holdings in Cullinan Therapeutics by 73.3% in the second quarter. Zurcher Kantonalbank Zurich Cantonalbank now owns 8,883 shares of the company’s stock valued at $155,000 after acquiring an additional 3,758 shares during the period. Rhumbline Advisers boosted its position in Cullinan Therapeutics by 16.4% in the second quarter. Rhumbline Advisers now owns 54,351 shares of the company’s stock worth $948,000 after purchasing an additional 7,649 shares during the last quarter. Arizona State Retirement System bought a new stake in shares of Cullinan Therapeutics during the 2nd quarter valued at about $182,000. Finally, American Century Companies Inc. increased its position in shares of Cullinan Therapeutics by 32.9% during the 2nd quarter. American Century Companies Inc. now owns 76,018 shares of the company’s stock valued at $1,326,000 after purchasing an additional 18,840 shares during the last quarter. Institutional investors own 86.31% of the company’s stock. About Cullinan Therapeutics ( Get Free Report ) Cullinan Therapeutics, Inc, a biopharmaceutical company, focuses on developing oncology therapies for cancer patients in the United States. The company's lead program comprises CLN-619, a monoclonal antibody that is in Phase I clinical trial for the treatment of solid tumors. Its development portfolio also includes CLN-049, a humanized bispecific antibody that is in Phase I clinical trial for the treatment of acute myeloid leukemia or myelodysplastic syndrome; CLN-418, a human bispecific immune activator that is in Phase 1 clinical trial for the treatment of multiple solid tumors; and Zipalertinib, a bioavailable small-molecule for treating patients with non-small cell lung cancer. See Also Receive News & Ratings for Cullinan Therapeutics Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for Cullinan Therapeutics and related companies with MarketBeat.com's FREE daily email newsletter .No. 7 Tennessee gives up 1st 14 points before rallying to rout Vanderbilt 36-23
BERKELEY, Calif. (AP) — Andrej Stojakovic converted 11 of 15 from the free throw line and scored 20 points as California held off a late rally to post an 83-77 win over Sacramento State in the Cal Classic tournament on Sunday. Cal came into its tournament without three starters, Jovan Blacksher Jr., DJ Campbell and BJ Omot and the Golden Bears earned back-to-back wins over Air Force and the Hornets. Stojakovic scored a career-high 21 points and freshman guard Jeremiah Wilkinson stepped up with career-best 23 points against the Falcons. Against Sacramento State, Wilkinson came off the bench to score 16 points. Sacramento State took an early 12-7 lead after Emil Skytta hit a pair of free throws five minutes into the game, but Wilkinson hit back-to-back buckets and Stojakovic drew a foul on a three-point attempt and hit all three foul shots to take a 14-12 lead and the Bears pulled away to take a 40-33 lead at intermission. Julian Vaughns knocked down a trey three minutes into the second half to pull Sacramento State even at 43 and his free throw put the Hornets in front. Ryan Petraitis and Wilkinson hit back-to-back 3-pointers to put Cal up 51-47 and the Bears never trailed the rest of the way. Petraitis finished with 13 points, five assists and three steals for Cal (5-1). Joshua Ola-Joseph and Mady Sissoko each added 10 points. Jacob Holt scored 25 points with eight rebounds, two assists and a steal to lead Sacramento State (1-4). Vaughns scored 18 points and EJ Neal added 16. The game was just the third meeting between schools separated by roughly 80 miles, and first since 1992. Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here . AP college basketball: https://apnews.com/hub/ap-top-25-college-basketball-poll and https://apnews.com/hub/college-basketball
A new federal rule will require water utilities across the country to pull millions of lead drinking water pipes out of the ground and replace them, at a cost of billions of dollars. States, cities and water utilities agree that the lead pipes need to go to ensure safe water for residents. But they say they may struggle to do so in the 10-year window required under the rule, and they fear some ratepayers will be hit with massive cost increases to pay for the work. State officials are urging Congress to provide ongoing funding for the lead replacement effort. Local leaders say they’ll need lots of help to meet the deadline. And environmental advocates are calling on states to issue bonds or provide other financial support to water utilities. “It took us close to 100 years to get all of these lead service lines in the ground, and the EPA is asking us to get them out in 10 years,” said Tom Dobbins, CEO of the Association of Metropolitan Water Agencies, an advocacy group for publicly owned water systems. “The [Biden] administration grossly underestimated the cost. Obviously, if the federal government doesn’t provide the funding for this, the ratepayers will have to pay for this. That exacerbates certain communities’ affordability issues.” The new rule, issued by the U.S. Environmental Protection Agency in October, requires cities and water utilities to replace all lead service lines — the pipes that run from water mains to private residences under lawns and sidewalks. Because the lines extend under private property, some water system operators say the rule has created confusion over whether utilities or homeowners will be responsible for the replacement costs. The EPA estimates that more than 9 million service lines are made of lead, a neurotoxin that can cause nervous system damage, learning disabilities and other health problems, especially in children. If lead pipes corrode, as in the infamous case of Flint, Michigan, they can poison drinking water. While no amount of lead exposure is safe, the federal rule now requires utilities to notify the public and improve corrosion treatment if lead in their water exceeds 10 parts per billion. Some homes in Syracuse, N.Y., recently tested at 70 parts per billion. “This is a significant public health advance,” said Erik Olson, who leads a drinking water protection campaign with the Natural Resources Defense Council, a national environmental nonprofit. “We’ve known for decades that lead service lines are dangerous, and, unfortunately, a lot of utilities just kept putting it on the back burner.” Under the rule, water systems will have until 2027 to draft a plan for replacing their lead lines, after which they will have 10 years to complete the work. Olson said President-elect Donald Trump, who has pledged to roll back many environmental regulations, would have a difficult time undoing the lead rule. A provision in the Safe Drinking Water Act prevents “backsliding” for federal protections, he said, and efforts to overturn the rule through Congress could prove deeply unpopular. Money worries The federal mandate comes after some states, including Illinois, Michigan and New Jersey, already issued their own lead replacement requirements and directed funding to their hardest-hit communities. “It’s a challenging goal, but I think we’ve shown it’s achievable,” said Eric Oswald, director of the Drinking Water and Environmental Health Division in the Michigan Department of Environment, Great Lakes, and Energy. “I’m trying to make Michigan the first state to remove all lead service lines.” The federal rule will accelerate Michigan’s timeline, as state regulations gave utilities a 20-year replacement window. But the initial state requirement has given water systems there a head start. Michigan has somewhere between 300,000 and 500,000 service lines, of which it’s replaced about 50,000 so far. Oswald acknowledged that the work will be expensive. In New Jersey, water utilities have replaced more than 25,000 service lines since a state lead law was passed in 2021 (that figure does not include a previous effort that replaced 23,000 pipes in Newark). But the state still has more than 120,000 lead service lines, which it said will cost at least $1.8 billion to replace. “There’s nothing yet that has made me think that it’s not achievable, but right now the focus has been on getting a good inventory,” said Trish Ingelido, director of water supply and geoscience at the New Jersey Department of Environmental Protection. “We’ll have a better sense in the next two years what the replacement rate is looking like.” The EPA estimates that the cost of replacing lead pipes nationwide will be about $45 billion. A separate analysis by the consulting firm Safe Water Engineering, funded by the Natural Resources Defense Council, arrived at a similar figure. But the American Water Works Association, a coalition of water system operators, puts the cost at closer to $90 billion. “This is important on the public health side, but it’s a challenge for local governments,” said Carolyn Berndt, legislative director for sustainability at the National League of Cities, which advocates for municipal governments. “We do see this raising concerns about affordability.” While local governments worry about expenses, the EPA says that the public health costs of lead poisoning are far greater. A federal analysis estimates that the rule, on an annual basis, will prevent 1,500 cases of premature death from heart disease and protect 900,000 infants from having low birthweight. The agency says the savings from avoiding the poisoning of residents will be 13 times greater than the cost of replacing the pipes. The feds have provided $15 billion for lead service line replacement through the 2021 infrastructure law passed by Congress, plus another $11.7 billion in state-administered drinking water funds that can be used for new lines. Some communities have used those federal grants and loans, along with pandemic relief funds, to make significant progress on their lead problem. So far, the EPA says it has distributed $9 billion of the money targeted at service line replacements, enough to change out up to 1.7 million pipes. But many water systems are still working to inventory their lead pipes, leaving them little time to compete for the federal funding that expires in 2026. “[Federal investments] provided significant new funding for this effort, but it’s absolutely not nearly enough for the successful implementation of the rule,” said Ben Grumbles, executive director of the Environmental Council of the States, a nonprofit association of environmental agency leaders. Grumbles noted that state agencies also are facing significant expenses from new federal rules to limit exposure to PFAS, or “forever chemicals,” in drinking water (lead, a naturally occurring metal, is not among the man-made PFAS chemicals). Cities struggle At the local level, leaders are scrounging for funding as best they can. “We’re looking at federal money, we’re looking at bonds, we’re looking at different loans and grants,” said Randy Conner, commissioner of the Chicago Department of Water Management. “We’re making sure we turn over all the couch cushions to find every quarter we can possibly find to put towards this effort.” Chicago has an estimated 400,000 lead pipes, more than any other U.S. city. Because of the sheer scale of the problem, the EPA gave Chicago an extended deadline of 20 years to replace its lines. Even so, that would require pulling out 19,000 lines a year, well more than the city’s current pace of 8,000. That work will cost about $780 million annually, according to city officials. Conner said the city is hoping for more federal and state support to avoid placing a heavy burden on ratepayers. Meanwhile, state and local leaders say Congress is interfering with a key source of money for lead line replacement. Two loan programs, funded by the federal government but administered by states, provide crucial financing for water infrastructure work. State agency leaders deploy the funding based on detailed assessments of community needs. But in recent years, members of Congress have bypassed states’ funding strategies to earmark money for projects in their districts. State agencies say they’re receiving less than half of the pool of money after Congress assigns its favored projects. That has left them less able to help the neediest communities. And many of the congressionally designated projects are lagging because they haven’t gone through the rigorous preparation work required by states. “By diverting so much funding away from the successful [loan programs], disadvantaged communities are less likely to get funding,” said Grumbles, who oversees the coalition of state agencies. Grumbles and others argue that any earmarks from Congress should only be in addition to the baseline loan program funding. Other challenges Costs aren’t the only obstacle water systems are facing. Some are concerned that the rush to replace millions of pipes nationwide will strain the workforce and supply chain capacity. “The limiting factor is going to be the availability of contractors and professionals and materials to do the actual work,” said Robert Boos, executive director of the Pennsylvania Infrastructure Investment Authority. “That’s going to be a national issue, when you’ve got tens of thousands of communities trying to do this work.” Pennsylvania has boosted clean water funding in its state budget, and it’s trying to tackle the workforce issue as well. Democratic Gov. Josh Shapiro signed an executive order in 2023 to create a workforce training program for infrastructure jobs, including lead pipe replacement. Olson, the environmental advocate, pointed to Newark, New Jersey, which partnered with a labor union to train local residents. The city replaced all of its 23,000 lead service lines in just over two years. “Creative thinking and political will are really what’s needed,” he said. “This is definitely doable.” Another potential problem is the fact that service lines lie under private property, meaning utilities need cooperation from homeowners to conduct the work. In some cases, they’ve run into opposition from residents or struggled to reach absentee landlords. “People just don’t trust government; they don’t think that anything is free,” said Conner, the Chicago official. “We want them to understand that we’re not coming into their house to give citations.” Environmental advocates also note that service lines’ placement on private property has created confusion over who must pay to replace them. The federal rule does not explicitly make water utilities responsible. “When the city goes to a household and says you have to pay a couple thousand dollars to replace your portion of the lead service line, it may work for higher-income people,” Olson said. “But the studies are showing that lower-income homeowners and landlords will not pay for it. It’s a real exacerbation of environmental injustices.” He pointed to Michigan, which adopted a rule specifying that water systems are responsible for the costs of replacing lines. He also noted that some cities have passed ordinances allowing residents of a home to authorize pipe replacement if a landlord can’t be reached.
Charles Schwab Investment Management Inc. lowered its stake in Commerce Bancshares, Inc. ( NASDAQ:CBSH – Free Report ) by 0.5% during the third quarter, according to the company in its most recent filing with the Securities & Exchange Commission. The firm owned 1,011,502 shares of the financial services provider’s stock after selling 4,652 shares during the quarter. Charles Schwab Investment Management Inc. owned about 0.79% of Commerce Bancshares worth $60,083,000 at the end of the most recent reporting period. Other hedge funds and other institutional investors have also made changes to their positions in the company. V Square Quantitative Management LLC acquired a new position in shares of Commerce Bancshares during the 3rd quarter worth about $26,000. Allworth Financial LP boosted its stake in Commerce Bancshares by 51.1% during the 3rd quarter. Allworth Financial LP now owns 568 shares of the financial services provider’s stock worth $34,000 after acquiring an additional 192 shares during the last quarter. Capital Performance Advisors LLP acquired a new position in Commerce Bancshares during the third quarter valued at approximately $39,000. GAMMA Investing LLC increased its stake in Commerce Bancshares by 156.5% in the second quarter. GAMMA Investing LLC now owns 854 shares of the financial services provider’s stock valued at $48,000 after purchasing an additional 521 shares in the last quarter. Finally, Farther Finance Advisors LLC raised its holdings in Commerce Bancshares by 48.2% in the third quarter. Farther Finance Advisors LLC now owns 882 shares of the financial services provider’s stock worth $52,000 after purchasing an additional 287 shares during the period. 70.26% of the stock is currently owned by institutional investors. Insider Activity at Commerce Bancshares In related news, SVP Patricia R. Kellerhals sold 2,000 shares of the stock in a transaction that occurred on Monday, September 16th. The stock was sold at an average price of $62.23, for a total transaction of $124,460.00. Following the completion of the transaction, the senior vice president now directly owns 23,381 shares of the company’s stock, valued at approximately $1,454,999.63. This represents a 7.88 % decrease in their ownership of the stock. The sale was disclosed in a document filed with the SEC, which is accessible through this hyperlink . Also, SVP David L. Roller sold 890 shares of the business’s stock in a transaction that occurred on Monday, November 18th. The stock was sold at an average price of $72.27, for a total value of $64,320.30. Following the transaction, the senior vice president now directly owns 30,949 shares in the company, valued at $2,236,684.23. This trade represents a 2.80 % decrease in their position. The disclosure for this sale can be found here . Over the last 90 days, insiders sold 35,109 shares of company stock valued at $2,191,123. Corporate insiders own 3.20% of the company’s stock. Commerce Bancshares Price Performance Commerce Bancshares ( NASDAQ:CBSH – Get Free Report ) last released its earnings results on Thursday, October 17th. The financial services provider reported $1.07 EPS for the quarter, beating the consensus estimate of $1.00 by $0.07. The firm had revenue of $421.38 million for the quarter, compared to analysts’ expectations of $412.85 million. Commerce Bancshares had a return on equity of 15.93% and a net margin of 24.15%. On average, equities analysts expect that Commerce Bancshares, Inc. will post 4.02 EPS for the current year. Commerce Bancshares Announces Dividend The firm also recently announced a quarterly dividend, which will be paid on Tuesday, December 17th. Investors of record on Tuesday, December 3rd will be issued a dividend of $0.27 per share. This represents a $1.08 annualized dividend and a yield of 1.46%. The ex-dividend date is Tuesday, December 3rd. Commerce Bancshares’s payout ratio is 28.13%. Analyst Upgrades and Downgrades Several equities analysts have recently issued reports on the stock. Piper Sandler set a $68.50 price target on shares of Commerce Bancshares and gave the company a “neutral” rating in a report on Friday, October 18th. StockNews.com raised Commerce Bancshares from a “sell” rating to a “hold” rating in a research report on Friday, October 18th. Finally, Morgan Stanley lowered Commerce Bancshares from an “overweight” rating to an “equal weight” rating and decreased their price objective for the company from $66.00 to $64.00 in a research report on Monday, September 30th. Seven analysts have rated the stock with a hold rating and one has issued a buy rating to the company’s stock. According to data from MarketBeat, Commerce Bancshares has an average rating of “Hold” and an average target price of $61.79. Read Our Latest Stock Report on CBSH Commerce Bancshares Company Profile ( Free Report ) Commerce Bancshares, Inc operates as the bank holding company for Commerce Bank that provides retail, mortgage banking, corporate, investment, trust, and asset management products and services to individuals and businesses in the United States. It operates through three segments: Consumer, Commercial, and Wealth. Recommended Stories Want to see what other hedge funds are holding CBSH? Visit HoldingsChannel.com to get the latest 13F filings and insider trades for Commerce Bancshares, Inc. ( NASDAQ:CBSH – Free Report ). Receive News & Ratings for Commerce Bancshares Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for Commerce Bancshares and related companies with MarketBeat.com's FREE daily email newsletter .
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Austin, November 30: Elon Musk's X has several fake accounts that resemble the actual account of a person or entity. These X parody accounts often have the same picture as the one they are mimicking, or they react to the post or repost with other quotes on the X platform. These accounts often use the word "Parody" to avoid confusion with the real person, which others mention in their bio. X parody accounts often confuse users on the platform when trying to identify whether they belong to a real person or not. These accounts mimic the lives of real-life people, such as politicians, film actors, artists, sports professionals, and others. Now, X may introduce a new feature on the platform that would show "Parody Account." Grok App Launching Soon: Elon Musk Confirms Introducing Mobile Application for His xAI’s Chatbot. According to a report by TechCrunch, Elon Musk's X is developing a new "label" for parody or fan commentary accounts. Using this capability or feature, the platform could distinctly show that the account is a "Parody Account" and not real. This could likely show on the profile page and in the posts they post on the X platform. Due to this, the report said that the chances of someone mixing or altering the original post or words from the real account would be less. Despite this development, the report said that Elon Musk's X would find it difficult to force accounts to apply labels to their profiles. X parody labels, if rolled out, would necessitate the platform changing its policies around satirical accounts. X currently has a dedicated policy called the "Authenticity Policy" to handle parody or satirical accounts on the platform. The policy asks these accounts to comply with X's rules and avoid impersonating other profiles to spread misinformation. The policy addresses Parody accounts, Commentary accounts, and Fan accounts. Users can operate accounts only if they discuss, satirise, and share information. Motorola Launches Moto AI Beta; Check Eligible Devices and Know How To Access. X parody labels could also help eliminate several accounts operated by automated bots. The report said that if the parody does not accept the labels, it might create confusion among users. (The above story first appeared on LatestLY on Nov 30, 2024 02:57 PM IST. For more news and updates on politics, world, sports, entertainment and lifestyle, log on to our website latestly.com ).Invest Smarter with the Piotroski Score: A Game-Changer on InvestingPro
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