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Türkiye, Iran, Russia and five Arab countries on Saturday urged a political solution in Syria to stop military operations there and protect civilians. In a joint statement released by the countries' foreign ministers after they met in Doha, they said the crisis in Syria posed a threat to regional and international security. The call was also echoed by U.N. Special Envoy for Syria Geir O. Pedersen. He called for urgent political talks in Geneva to implement U.N. Security Council Resolution 2254, urging immediate action to address the ongoing crisis in Syria. "The situation is changing by the minute. So when I'm addressing you, things are changing inside of Syria,” Pedersen said at a press conference in the Qatari capital, where the two-day Doha Forum 2024 began on Saturday. Pedersen said he has held discussions with foreign ministers from Türkiye, Iran, and Russia, as well as officials from the U.S., France, U.K., Germany, and EU, and "I have called for urgent political talks in Geneva to implement Security Council Resolution 2254.” "I'm pleased to say that the ministers and all I'm talking to are backing this call. My hope is that I will be able to announce a date for this very soon,” he asserted. The special envoy stressed the importance of a new approach, saying, "The need for an orderly political transition has never been more urgent starting with the urgent formation of inclusive and credible transitional arrangements in Syria. For this we need an urgent serious process fundamentally different from what has gone on before.” He reiterated the need to reduce tensions, restore calm, avoid bloodshed, and protect civilians in accordance with international humanitarian law. The two-day Doha Forum 2024 is being held in Doha with the theme "The Inevitability of Innovation." According to official estimates, over 4,500 participants from more than 150 countries are in attendance, including seven heads of state, seven prime ministers and 15 foreign ministers.​​​​​​​

Interviews with college football coaches heading into halftime of games can often be anodyne. As his Texas team competes for a conference title on Saturday, Steve Sarkisian provided a notable exception. Despite the No. 2 Longhorns leading No. 5 Georgia 6-3 at halftime of the 2024 SEC championship game Saturday at Mercedes-Benz Stadium in Atlanta, Sarkisian’s squad spent the opening 30 minutes of the matchup mired in mistakes, finishing the first half with eight penalties for 80 yards. REQUIRED READING: Texas vs Georgia live score updates, highlights, how to watch SEC championship game When asked by ESPN’s Laura Rutledge about how Texas cleans up that sloppiness, Sarkisian provided a succinct and pointed answer. “Well, hopefully they call them for a holding one of these times, too,” Sarkisian said , with no further elaboration or comment beyond his brief statement. In contrast to the Longhorns , Georgia had just two penalties for 19 yards in the first two quarters of action. The penalty disparity was one of several factors that kept coach Kirby Smart’s team down just three points after being statistically dominated in the first half. Texas outgained the Bulldogs by a 260-54 margin in the opening two quarters. Several of the Longhorns’ penalties negated big plays that could have ultimately led to precious points in a low-scoring game. Texas entered Saturday’s game No. 62 among 134 FBS teams in penalty yards per game, with 50.3.Lana Del Rey Makes Rare Comments About Husband Jeremy Dufrene, Reveals Another Celebrity Who Inspired Her Love StoryYOUNGSTOWN, Ohio (AP) — EJ Farmer's 22 points helped Youngstown State defeat Oakland 66-50 on Saturday. Farmer shot 7 for 13 (5 for 8 from 3-point range) and 3 of 3 from the free-throw line for the Penguins (5-5, 2-0 Horizon League). Nico Galette scored 11 points and added nine rebounds and six assists. Juwan Maxey and Jason Nelson both added 11 points. Allen David Mukeba Jr. led the Golden Grizzlies (3-5, 1-1) in scoring, finishing with 17 points. Tuburu Niavalurua added 12 points for Oakland. D.Q. Cole had 11 points. NEXT UP Up next for Youngstown State is a Saturday matchup with Toledo at home, and Oakland plays Michigan State on Tuesday. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .

Patriots coach Jerod Mayo heard the ‘Fire Mayo’ chants and understands crowd’s frustrationsTwo goals from Joseph Paintsil and Dejan Joveljic within the game’s first 13 minutes catapulted the Los Angeles Galaxy to their sixth-ever MLS Cup title, defeating the New York Red Bulls 2-1 on Saturday evening at Dignity Health Sports Park in Carson, CA. New York’s wait for a first-ever MLS Cup continues as one of the league’s inaugural franchises fell in just its second-ever championship game appearance, which came 16 years ago in 2008 against the Columbus Crew. It was as shaky a start as possible for New York, which looked to be in shambles after being forced to make a late switch in the back line when center-back Andres Reyes was scratched just moments before kick-off due to illness. Noah Eile, the 22-year-old Swede, was alerted five minutes before his team took the pitch that he would start. Painstil was played through and was kept onside by Eile, who sagged just a step too deep, allowing the speedy Galaxy forward to get in on goal and sneak a low shot under goalkeeper Carlos Coronel in the ninth minute. Joveljic made it 2-0 just four minutes later when he walked in on goal between a loose Red Bulls defense and poked a tepid shot just inside the left post. As they had all season, though, the Red Bulls found a response in the 28th minute off a corner kick. After the ball pinged around the box, it fell to Sean Nealis, who took it off the chest and finished the half-volley into the right side of the goal to halve New York’s deficit. The sudden jolt from the former captain sprang the Red Bulls to life, as they settled into the game and ultimately evened run of play while searching for an equalizer. Chances were traded throughout, including a post from each team. Los Angeles’ Miki Yamane struck the right post from the right side of the box in the 65th minute. In the 71st minute, a save by Coronel on Gabriel Pec sparked a Red Bulls counter-attack that ended with Emil Forsberg just grazing the outside of the right post.

Shares of Mineralys Therapeutics, Inc. ( NASDAQ:MLYS – Get Free Report ) traded down 4.1% during mid-day trading on Thursday . The company traded as low as $12.11 and last traded at $12.28. 6,387 shares changed hands during mid-day trading, a decline of 96% from the average session volume of 179,628 shares. The stock had previously closed at $12.80. Wall Street Analysts Forecast Growth Separately, HC Wainwright reiterated a “buy” rating and set a $30.00 target price on shares of Mineralys Therapeutics in a report on Tuesday, November 12th. View Our Latest Analysis on Mineralys Therapeutics Mineralys Therapeutics Stock Performance Mineralys Therapeutics ( NASDAQ:MLYS – Get Free Report ) last announced its earnings results on Monday, November 11th. The company reported ($1.13) earnings per share for the quarter, missing the consensus estimate of ($0.83) by ($0.30). During the same quarter in the prior year, the business posted ($0.57) earnings per share. Sell-side analysts anticipate that Mineralys Therapeutics, Inc. will post -3.63 earnings per share for the current year. Insiders Place Their Bets In other Mineralys Therapeutics news, insider David Malcom Rodman sold 25,482 shares of the firm’s stock in a transaction on Wednesday, November 6th. The shares were sold at an average price of $15.03, for a total transaction of $382,994.46. Following the completion of the transaction, the insider now directly owns 135,974 shares of the company’s stock, valued at $2,043,689.22. This trade represents a 15.78 % decrease in their position. The sale was disclosed in a legal filing with the Securities & Exchange Commission, which is available at the SEC website . Also, CEO Jon Congleton sold 15,271 shares of the company’s stock in a transaction dated Friday, October 11th. The shares were sold at an average price of $13.52, for a total transaction of $206,463.92. Following the completion of the sale, the chief executive officer now owns 895,941 shares in the company, valued at approximately $12,113,122.32. This trade represents a 1.68 % decrease in their position. The disclosure for this sale can be found here . Insiders have sold 51,510 shares of company stock worth $735,431 in the last three months. 33.24% of the stock is owned by insiders. Institutional Inflows and Outflows A number of large investors have recently bought and sold shares of the company. Franklin Resources Inc. raised its position in shares of Mineralys Therapeutics by 17.7% during the 3rd quarter. Franklin Resources Inc. now owns 1,745,513 shares of the company’s stock valued at $21,138,000 after acquiring an additional 262,922 shares in the last quarter. Caligan Partners LP increased its stake in Mineralys Therapeutics by 31.6% during the third quarter. Caligan Partners LP now owns 981,155 shares of the company’s stock valued at $11,882,000 after purchasing an additional 235,397 shares during the last quarter. Nantahala Capital Management LLC raised its holdings in shares of Mineralys Therapeutics by 60.1% during the second quarter. Nantahala Capital Management LLC now owns 532,506 shares of the company’s stock worth $6,230,000 after purchasing an additional 200,000 shares during the period. Ikarian Capital LLC acquired a new stake in shares of Mineralys Therapeutics during the third quarter worth $2,180,000. Finally, Driehaus Capital Management LLC lifted its position in shares of Mineralys Therapeutics by 40.4% in the 2nd quarter. Driehaus Capital Management LLC now owns 257,371 shares of the company’s stock worth $3,011,000 after buying an additional 74,074 shares during the last quarter. Institutional investors own 84.46% of the company’s stock. Mineralys Therapeutics Company Profile ( Get Free Report ) Mineralys Therapeutics, Inc, a clinical-stage biopharmaceutical company that develops therapies for the treatment of hypertension and chronic kidney diseases. It clinical-stage product candidate is lorundrostat, a proprietary, orally administered, highly selective aldosterone synthase inhibitor for the treatment of cardiorenal conditions affected by abnormally elevated aldosterone. Featured Stories Receive News & Ratings for Mineralys Therapeutics Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for Mineralys Therapeutics and related companies with MarketBeat.com's FREE daily email newsletter .With home field clinched for CUSA title game, Jax State has more goals on its plateNone

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Cardiol Therapeutics Inc. ( TSE:CRDL – Get Free Report ) Senior Officer Guillermo Torre bought 17,240 shares of the company’s stock in a transaction that occurred on Thursday, December 26th. The stock was purchased at an average cost of C$1.81 per share, with a total value of C$31,277.77. Cardiol Therapeutics Price Performance TSE:CRDL opened at C$1.89 on Friday. The stock has a market cap of C$132.07 million, a PE ratio of -4.30 and a beta of 0.70. The company has a quick ratio of 6.84, a current ratio of 2.39 and a debt-to-equity ratio of 1.07. The business’s 50-day simple moving average is C$2.29 and its two-hundred day simple moving average is C$2.64. Cardiol Therapeutics Inc. has a 52 week low of C$1.09 and a 52 week high of C$4.26. About Cardiol Therapeutics ( Get Free Report ) See Also Receive News & Ratings for Cardiol Therapeutics Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for Cardiol Therapeutics and related companies with MarketBeat.com's FREE daily email newsletter .LONDON , Nov. 26, 2024 /PRNewswire/ -- The EY organization announces today the appointment of Joe Depa as the new EY Global Chief Innovation Officer, effective immediately. Within this role, he will spearhead applied innovation to help improve service delivery and guide EY teams to address and solve business challenges. Depa joins the EY organization at a pivotal moment, as a range of emerging technologies are reshaping businesses and industries, creating a multitude of new challenges and opportunities. To keep pace, the EY organization is continuing to make significant investments in areas such as artificial intelligence (AI), quantum computing and blockchain, and most recently formed the EY.ai Global AI Advisory Council. In his new role, Depa will be leading the organization's global innovation strategy. This will include overseeing efforts to successfully implement emerging technologies for tangible business applications, both internally and across work of EY member firms with clients. Raj Sharma, EY Global Managing Partner of Growth and Innovation, says: "At this time of constant disruption, success would require a forward-thinking approach and willingness to make bold decisions, which are at the heart of an innovative mindset. We're thrilled to have Joe's deep experience and knowledge around AI and data to lead on our strategic approach to innovation so that EY teams can help clients shape their future more confidently." Throughout the last decade, Depa has worked closely with C-suite leaders and boards to bring innovative products and services to market, improve client and employee experiences, and help enhance operational efficiencies through technology. Most recently, he served as the inaugural Chief Data and AI Officer at a leading university and health care organization. At the university, he helped to promote AI literacy, launch a responsible AI governance program and enable a secure data foundation. Prior to that, he acted as Senior Managing Director and Global Lead for Data and AI at a global multinational professional services company, where he led a team of AI strategists and data engineers in developing and implementing new products and services. Joe Depa , EY Global Chief Innovation Officer, says: "I'm truly excited to join an organization that is 'All in' on its commitment to the transformative potential of emerging technologies. I look forward to working with the EY teams and clients to help empower them to apply innovation in bold, new ways that help create value for clients through data, AI and emerging technologies to make the world a better place." A renowned thought leader in the field of AI, Depa has been recognized as one of the "Top 50 Global Leaders" by World Summit AI and has received Fast Company's "World Changing Idea" award, among other accolades. For more information, visit: ey.com . About EY EY is building a better working world by creating new value for clients, people, society and the planet, while building trust in capital markets. Enabled by data, AI and advanced technology, EY teams help clients shape the future with confidence and develop answers for the most pressing issues of today and tomorrow. EY teams work across a full spectrum of services in assurance, consulting, tax, strategy and transactions. Fueled by sector insights, a globally connected, multi-disciplinary network and diverse ecosystem partners, EY teams can provide services in more than 150 countries and territories. All in to shape the future with confidence. EY refers to the global organization, and may refer to one or more, of the member firms of Ernst & Young Global Limited, each of which is a separate legal entity. Ernst & Young Global Limited, a UK company limited by guarantee, does not provide services to clients. Information about how EY collects and uses personal data and a description of the rights individuals have under data protection legislation are available via ey.com/privacy . EY member firms do not practice law where prohibited by local laws. For more information about our organization, please visit ey.com . This news release has been issued by EYGM Limited, a member of the global EY organization that also does not provide any services to clients. View original content to download multimedia: https://www.prnewswire.com/news-releases/joe-depa-named-as-ey-global-chief-innovation-officer-to-lead-its-global-innovation-strategy-302316910.html SOURCE EYGS LLP

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BOONE, N.C. (AP) — South Carolina offensive coordinator Dowell Loggains has been hired as head coach at Appalachian State and will receive a five-year contract, athletic director Doug Gillin announced Saturday. The 44-year-old Loggains replaces Shawn Clark, who was fired Monday after the Mountaineers finished 5-6 for their first losing season since 2013. Loggains was South Carolina's offensive coordinator for two seasons and an assistant at Arkansas, his alma mater, for two seasons before that. He spent 16 years in the NFL as offensive coordinator and quarterbacks coach for Tennessee, Cleveland, Chicago, Miami and the New York Jets. “He brings experience as a leader and play-caller at the highest levels of professional and college football," Gillin said. "He is a great recruiter and believes strongly in building relationships. He is aligned with our core values of academic integrity, competitive excellence, social responsibility and world-class experience. This is a great day for App State.” Loggains' offense at South Carolina featured LaNorris Sellers, one of the nation's top dual-threat quarterbacks, and running back Raheim “Rocket” Sanders. Sellers and Sanders led the Southeastern Conference's third-ranked rushing offense. Loggains spent the 2021 and 2022 seasons as Arkansas' tight ends coach, and he worked with Sam Darnold, Jay Cutler, Mitchell Trubisky, Brian Hoyer and Vince Young during his time in the NFL. The Mountaineers, the preseason favorites in the Sun Belt Conference's East Division, tied for fifth with a 3-5 record in league play. App State was 40-24 under Clark, but the Mountaineers have failed to reach a bowl game two of the past three seasons. Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here . AP college football: https://apnews.com/hub/ap-top-25-college-football-poll and https://apnews.com/hub/college-footballDigitisation drives more sustainable and efficient car repair practicesFor years, patients in the U.S. health care system have grown frustrated with a bureaucracy they don’t understand. Doctors are included in an insurer’s network one year but not the next. Getting someone on the phone to help can be next to impossible. Coverage of care and prescriptions is often unceremoniously denied. This week’s fatal shooting of UnitedHealthcare CEO Brian Thompson has unleashed a wave of public feeling — exasperation, anger, resentment, helplessness — from Americans sharing personal stories of interactions with insurance companies, often seen as faceless corporate giants. In particular, the words written on ammunition found at the shooting scene — “delay,” “deny” and “depose,” echoing a phrase used to describe how insurers dodge claim payouts — amplified voices that have long been critical of the industry. “All of a sudden, I am fired up again,” said Tim Anderson, describing how his wife, Mary, had to deal with UnitedHealthcare coverage denials before she died from Lou Gehrig’s disease, or amyotrophic lateral sclerosis, in 2022. Anderson said they couldn’t get coverage for machines to help his wife breathe or talk — toward the end, she communicated by blinking when he showed her pictures. The family had to rely on donations from a local ALS group, he said. “The business model for insurance is don’t pay,” said Anderson, 67, of Centerville, Ohio. “When Mary could still talk, she said to me to keep fighting this,” he added. “It needs to be exposed.” For Anderson and others, Thompson’s death and the message left at the scene have created an opportunity to vent their frustrations. Conversations at dinner tables, office water coolers, social gatherings and on social media have pivoted to the topic, as police efforts to find the gunman keep the case in the news. Hans Maristela said he understands why the chatter is bubbling up. The 54-year-old caregiver in California was moved to comment on Facebook about UnitedHealthcare’s reputation of denying coverage. As a Catholic, he said, he grieves Thompson’s death and feels for his family, especially with the holidays around the corner. But he sees frustration with insurers even among his clients, most of them wealthy older people who’ve not been shielded from high out-of-pocket costs. “And then you know the CEO of this company you pay a lot of money to gets $10 million dollars a year, you won’t have a lot of sympathy for the guy,” Maristela said, citing Thompson’s compensation package that included base pay and stock options. “Health care is a business, I understand, but the obsession with share price, with profit, has to be reevaluated.” University of Pennsylvania researcher Michael Anne Kyle said she’s not surprised by the growth of conversation around insurers. “People are often struggling with this by themselves, and when you see someone else talk about it, that may prompt you to join the conversation,” she said. Kyle studies how patients access care and said she’s seen frustration with the system build for years. Costs are rising, and insurers are using more controls such as prior authorizations and doctor networks to manage them. Patients are often stuck in the middle of disputes between doctors and insurers. “Patients are already spending a lot of money on health care, and then they’re still facing problems with the service,” she said. Insurers often note that most of the money they bring in goes back out the door to pay claims, and that they try to corral soaring costs and the overuse of some care. In Ohio, Anderson said his initial reaction to the CEO shooting was to question whether it was connected to a coverage denial, like the ones he’d experienced with his wife. “I definitely do not condone killing people,” he said. “But I read it and said, ‘I wonder if somebody had a spouse whose coverage was denied.’” It’s something Will Flanary, a Portland-based ophthalmologist and comedian with a large social media following, saw online a lot in the shooting’s immediate aftermath and found very telling. “It’s zero sympathy,” he said. “And the lesson to take away from that is not, ‘Let’s shame people for celebrating a murder.’ No, it’s: ‘Look at the amount of anger that people have toward this system that’s taken advantage of people and do something to try to fix that.’” Flanary’s content, published under the name Dr. Glaucomflecken, started out as niche eye doctor jokes and a way to cope with his own experiences with two cancer diagnoses and a sudden cardiac arrest. But it has evolved, featuring character skits that call attention to and satirize the decisions of large health insurers, including UnitedHealthcare. He said he’s never seen conversations around health insurance policy take off the way they did this week — and he hopes these new voices can help bring about change. “I’m always talking about how powerful social media can be with advocacy,” he said, “because it really is the only way to put a significant amount of pressure on these corporations who are doing bad things for patients.”